Dante’s Inferno: a helpful diagram to eternal damnation
Feeding the wild Teddy Bears
THIS FUCKED ME IP
BLESS THIS FUCKING CHILD OMG
sometimes i look at people on my dash and i think
who the fuck are you
when did i follow you
you’re not posting things relative to my interests
but i can’t unfollow you becasue i can’t remember why i did
it might have been important
This is the most accurate post I have ever seen on here.
A class of bacteria commonly found in the guts of people—and rodents—appears to keep mice safe from food allergies, a study suggests.
The same bacteria are among those reduced by antibiotic use in early childhood. The research fits neatly into an emerging paradigm that helps explain a recent alarming increase in food allergies and other conditions, such as obesity and autoimmune disease, and hints at strategies to reverse the trend.
Food allergies have increased about 50% in children since 1997. There are various theories explaining why. One is that the 21st century lifestyle, which includes a diet very different from our ancestors’, lots of antibiotic use, and even a rise in cesarean section deliveries, has profoundly changed the makeup of microbes in the gut of many people in developed countries. For example, the average child in the United States has taken three courses of antibiotics by the time he or she is 2 years old, says Martin Blaser, an infectious disease specialist and microbiologist at New York University in New York City. (See here for more on the reach of microbiome research these days.)
Cathryn Nagler, an immunologist at the University of Chicago in Illinois, has spent years probing links between the immune system, intestinal bacteria, and the onset of allergies. Back in 2004, she and her colleagues reported that wiping out gut bacteria in mice led to food allergies. Since then, Nagler has continued trying to understand which bacteria offer allergy protection and how they accomplish that.
In one of the latest efforts, Nagler’s team first confirmed that mice given antibiotics early in life were far more susceptible to peanut sensitization, a model of human peanut allergy. Then, they introduced a solution containing Clostridia, a common class of bacteria that’s naturally found in the mammalian gut, into the rodents’ mouths and stomachs. The animals’ food allergen sensitization disappeared, the team reports online today in the Proceedings of the National Academy of Sciences. When the scientists instead introduced another common kind of healthy bacteria, called Bacteroides, into similarly allergy-prone mice, they didn’t see the same effect. Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream. “The bacteria are maintaining the integrity of the [intestinal] barrier,” Nagler says.
The research “opens up new territory,” Blaser says. It “extends the frontier of how the microbiome is involved” in immune responses and the roles played by specific bacteria. (Blaser’s group reported earlier this month in Cell that giving mice penicillin soon after birth changed their gut microbiome and made them much more likely to be obese as adults.) Nagler and her university have filed for a patent application on the new findings. The ultimate goal is to “interrupt [the allergy] process by manipulating the microbiota,” she says—a probiotic consisting of Clostridia could be a new allergy therapy, for example. Nagler knows of none on the market yet, and they would need testing in people before becoming a treatment of choice.
Reid Wiseman is a national treasure.
Pug gets scolded by owner and takes it to heart
I FEEL SO SAD SEEING THE DOG’S FACE
OH MY GOD
Bubonic plague found in Colorado fleas
Health officials say the plague is unlikely to spread, but locals should be on the lookout for symptoms and take precautions with their pets.
everyone watch this video of my dog gettin embarrassed that i caught him singin
Solar energy that doesn’t block the view
A team of researchers at Michigan State University has developed a new type of solar concentrator that when placed over a window creates solar energy while allowing people to actually see through the window. It is called a transparent luminescent solar concentrator and can be used on buildings, cell phones and any other device that has a clear surface. And, according to Richard Lunt of MSU’s College of Engineering, the key word is “transparent.”
A modern living room is played up with perfect lighting. That sculptural pendant light is actually made by grouping many of the same type of pendant. See more of this look.